Salmonella and Caspase-1: A complex Interplay of Detection and Evasion

Salmonellae are intracellular pathogens that replicate within epithelial cells and macrophages, and are a significant public health threat in both developed and developing countries. The innate immune system detects microbes through pattern recognition receptors, which are compartmentalized on the subcellular level to detect either extracellular (e.g., TLRs) or cytosolic (e.g., NLRs) perturbations. Salmonella infection is detected by the NLRC4 and NLRP3 inflammasomes, which activate Caspase-1, resulting in reduced bacterial burdens during infection. NLRC4 responds to the SPI1 type III secretion system via detection of inadvertently translocated flagellin and rod protein. The signals for NLRP3 detection during Salmonella infection remain undefined. Salmonella have evolved evasion strategies to attenuate Caspase-1 responses. We review recent findings describing the interplay between detection and evasion of S. typhimurium infection by the inflammasome. We discuss how the interplay between detection and evasion affects Caspase-1 effector functions mediated by IL-1β secretion, IL-18 secretion, and pyroptosis

EFFICIENCY AND PRODUCTIVITY GROWTH IN INDIAN BANKING

This paper attempts to examine technical efficiency and productivity performance of Indian scheduled commercial banks, for the period 1979-2008. We model a multiple output/multiple input technology production frontier using semiparametric estimation methods. The endogenity of multiple outputs is addressed by semi parametric estimates in part by introducing multivariate kernel estimators for the joint distribution of the multiple outputs and correlated random effects. Output is measured as the rupee value of total loans and total investments at the end of the year. The estimates provide robust inferences of the productivity and efficiency gains due to economic reforms.Banking, Frontier efficiency, Productivity

Correlation between elevated serum ferritin and HbA1c in type 2 diabetes mellitus

Background: Serum Ferritin, an acute phase reactant is a marker of iron stores in the body. Recent studies indicate that increased body iron stores and subclinical hemochromatosis has been associated with the development of glucose intolerance, type 2 diabetes, metabolic syndrome and possibly the development of diabetic retinopathy, nephropathy and vascular dysfunction. This study was carried out to examine and establish a relationship between Serum Ferritin with Type 2 diabetes mellitus and metabolic syndrome and to examine whether a correlation between S. ferritin and FBS, HbA1c exists.Methods: 86 type 2 diabetes subjects (M:F - 57:29, mean age 54.3±9.2 years, mean BMI 24.28kg/m2) which included 24 patients with metabolic syndrome were studied and compared with controls. S. ferritin, Hb, ESR, FBS, PPBS, HbA1c and fasting lipid profile were measured.Results: Serum ferritin was significantly higher in diabetic patients when compared to controls and serum ferritin had a positive correlation with increasing duration of diabetes.Conclusions: There was a positive correlation between serum ferritin and FBS, HbA1c. There was no correlation between serum ferritin and age, sex, metabolic syndrome, coexistent hypertension, total cholesterol, LDL and serum triglycerides.

Chromium uptake by Fenugreek

Fenugreek (Trigonella foenum- graecum) is both herb (leaves) and a spice (seed) belonging to the family Fabaceae. Fenugreek leaves and seeds are used in the cuisine of India. Fenugreek also has medicinal value. Fenugreek seeds are known to reduce serum glucose and improve glucose tolerance and hence are prescribed to diabetic patients. In the recent past supplemental Chromium is being prescribed to diabetic patients to activate (increased- insulin binding, insulin receptor number, insulin receptor phosphorylation) insulin. Plants can uptake substantial quantities of toxic metals from contaminated soils if these soils are well ameliorated. 

It is then probable that the medicinal efficacy of Fenugreek in the case of diabetes could be enhanced if it takes up chromium from the soil. Preliminary studies are being conducted to note the chromium uptake by Fenugreek from soils which are applied with potassium dichromate

Studies on the Accumulation of Chromium in Fenugreek

Studying Cr uptake by Fenugreek, we note that the maximum concentration of Cr takes place in the shells of the pods followed by leaves, stems and seeds in that order. Interestingly, applied higher doses of Cr does not increase accumulation of Cr in the stems, rather Cr content in the stems levels off. However, the maximum dispersal/distribution of Cr taken up is in the leaves

VOICE RECOGNIZATION FOR MOUSE CONTROL USING HCI

One  of  the  most  important  research  areas  in  the  field  of  Human -Computer-Interaction (HCI) is gesture  recognition as it provides a natural and intuitive  way  to  communicate  between  people  and  machines.  Voice-based HCI applications range from computer applications to virtual/augmented reality and is recently being explored in other fields. This work proposes the implementation of absolute virtual mouse based on the interpretation of voice reorganization control. The procedure is to control the mouse pointer as for the mouse movement to up/down/left/right, open the file, dragging the file. This  virtual  device  is designed  specifically  as  an  alternative non-contact  pointer  for  people  with mobility impairments in the upper extremities. The implementation of the virtual mouse by voice control is to make HCI simplification for disabled persons especially for the person who are not having the hands and arms, and Alternative mouse cursor positioning system for laptops

Familial esophageal achalasia in mother and son

Familial esophageal achalasia a rare presentation, is most often described in monozygotic twins or siblings. Parent/child association is very rare and exhaustive review of the literature found about 5 times as many instances of affected siblings than instances of affected parent/child. Only seven instances of parent/child association have been reported till date. We report a 75 -year-old lady with achalasia cardia and her son who developed the same illness one year later. Mother was treated by Heller's surgery and son is presently on medical management